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KMID : 0043319970200040324
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Archives of Pharmacal Research
1997 Volume.20 No. 4 p.324 ~ p.329
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Clonazepam Release from Core-shell Type Nanoparticles In Vitro
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Kim Hyun-Jung
Jeong Young-Il
Kim Sung-Ho
Lee Young-Moo
Cho Chong-Su
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Abstract
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AB-type amphiphilic copolymers (abbreviated as LE) composed of poly (L-leucine) (PLL) as the A component and poly (ethylene oxide) (PEO) as the B component were synthesized by the ring-opening polymerization of L-leucine N-carboxy-anhydride initiated by methoxy polyoxyethylene amine and characterized. Core-shell type nanoparticles were prepared by the diafiltration method. Particle size distribution obtained by dynamic light scattering was dependent on PLL composition and the size for LE-1, LE-2 and LE-3 was , and , respectively. Shapes of the nanoparticies observed by transmission electron microscope (TEM) were almostly spherical. The critical micelle concentration (CMC) of the nanoparticles determined by a fluorescence probe technique was dependent on the composition of hydrophobic PLL, and the CMC for LE-1, LE-2 and LE-3 was and , respectively. Clonazepam release from core-shell type nanoparticles in vitro was dependent on PLL composition and drug loading content.
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KEYWORD
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Core-shell type nanoparticle, Diafiltration method, Critical micelle concentration Amphiphilic copolymers
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